PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
All Product Categories
-
PROTAC Linkers Related Products (4098)
Related Products (4098)
-
PROTAC Linkers Isoform Comparison
-
Boc-2-(piperazin-1-yl)acetic acid dihydrate
0 ImagesCat. No.: HY-W102047CAS No.: 1049785-94-5
-
2-(1-((Benzyloxy)carbonyl)piperidin-4-yl)acetic acid
0 ImagesCat. No.: HY-W021675CAS No.: 63845-28-3
-
4-Chlorobutanal
0 ImagesCat. No.: HY-W611693CAS No.: 6139-84-0
-
6-(((Benzyloxy)carbonyl)amino)hexyl 4-methylbenzenesulfonate
0 ImagesCat. No.: HY-W573219CAS No.: 51224-12-5
-
Oct-7-yn-1-yl 4-methylbenzenesulfonate
0 ImagesCat. No.: HY-W877039CAS No.: 219982-82-8
-
Suberic acid monomethyl ester (Standard)
0 ImagesCat. No.: HY-W001958RCAS No.: 3946-32-5Suberic acid monomethyl ester (Standard) is the analytical standard of Suberic acid monomethyl ester (HY-W001958). This product is intended for research and analytical applications. Suberic acid monomethyl ester is an ester product. Suberic acid monomethyl ester is a PROTAC linker that can be used in the synthesis of PROTACs, DDD2 (HY-176261).
-
Bis-(N,N'-PEG4-NHS ester)-Cy5
0 ImagesCat. No.: HY-141047CAS No.: 2107273-48-1
-
Phenylmethyl N-(2-aminoethyl)-N-methylcarbamate
0 ImagesCat. No.: HY-W582700CAS No.: 19023-94-0
-
Fmoc-NH-PEG5-C2-NH2 hydrochloride
0 ImagesCat. No.: HY-134682APurity: 98.98%
-
Benzyl (5-aminopentyl)carbamate
0 ImagesCat. No.: HY-W574973CAS No.: 69747-36-0
-
tert-Butyl 4-oxobutanoate
0 ImagesCat. No.: HY-W615225CAS No.: 51534-77-1
-
GGG-PEG5-BCN
0 ImagesCat. No.: HY-W1130398
-
tert-Butyl 3,3-difluoro-4-((methylsulfonyloxy)methyl)piperidine-1-carboxylate
0 ImagesCat. No.: HY-W001728CAS No.: 1864060-27-4
-
Tert-butyl 2-(2-aminoethyl)-2,8-diazaspiro[4.5]Decane-8-carboxylate
![Tert-butyl 2-(2-aminoethyl)-2,8-diazaspiro[4.5]Decane-8-carboxylate](https://file.medchemexpress.com/product_pic/hy-w383170.gif "Click to View Tert-butyl 2-(2-aminoethyl)-2,8-diazaspiro[4.5]Decane-8-carboxylate Product Detail")
0 ImagesCat. No.: HY-W383170CAS No.: 1420876-70-5
-
1-Isothiocyanato-PEG3-azide
0 ImagesCat. No.: HY-140843CAS No.: 1310686-23-71-Isothiocyanato-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. 1-Isothiocyanato-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
-
2-(5-Bromopentyl)-1,3-dioxolane
0 ImagesCat. No.: HY-W666697CAS No.: 56741-68-5
-
HO-PEG6-CH2COOH
0 ImagesCat. No.: HY-133302CAS No.: 120394-66-3
-
Methyl 4-formylbicyclo[2.2.2]octane-1-carboxylate
![Methyl 4-formylbicyclo[2.2.2]octane-1-carboxylate](https://file.medchemexpress.com/product_pic/hy-w048974.gif "Click to View Methyl 4-formylbicyclo[2.2.2]octane-1-carboxylate Product Detail")
0 ImagesCat. No.: HY-W048974CAS No.: 94994-25-9
